PCI Genomics

293

Title *

Transposable element expression with variation in sex chromosome number supports a toxic Y effect on human longevityuse asterix (*) to get italics

Authors *

Jordan Teoli, Miriam Merenciano, Marie Fablet, Anamaria Necsulea, Daniel Siqueira-de-Oliveira, Alessandro Brandulas-Cammarata, Audrey Labalme, Hervé Lejeune, Jean-François Lemaitre, François Gueyffier, Damien Sanlaville, Claire Bardel, Cristina Vieira, Gabriel AB Marais, Ingrid PlottonPlease use the format "First name initials family name" as in "Marie S. Curie, Niels H. D. Bohr, Albert Einstein, John R. R. Tolkien, Donna T. Strickland"

Year *

2023

Picture *

Abstract *

<p>Why women live longer than men is still an open question in human biology. Sex chromosomes have been proposed to play a role in the observed sex gap in longevity, and the Y male chromosome has been suspected of having a potential toxic genomic impact on male longevity. It has been hypothesized that in aging individuals, where TE repression is diminished, an increase in somatic mutations and an acceleration of the aging process may occur. As the Y chromosome is typically enriched in transposable elements (TE), this could explain why the presence of a Y chromosome is associated with shorter longevity. Using transcriptomic data from humans with atypical karyotypes, we found an association between TE expression and the presence and number of Y chromosomes. These findings support the existence of a toxic Y effect on men's longevity.</p>

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https://doi.org/10.1101/2023.08.03.550779You should fill this box only if you chose 'All or part of the results presented in this preprint are based on data'. URL must start with http:// or https://

Indicate the full web address (DOI or URL) giving public access to these scripts (if you have any problems with the deposit of your scripts, please contact contact@genomics.peercommunityin.org). In case all raw scripts are included in the preprint, indicate the DOI or URL of the preprint. *

https://github.com/teolijo/longevitY/blob/main/pipelineYou should fill this box only if you chose 'Scripts were used to obtain or analyze the results'. URL must start with http:// or https://

Indicate the full web address (DOI, SWHID or URL) giving public access to these codes (if you have any problems with the deposit of your codes, please contact contact@genomics.peercommunityin.org). In case all raw codes are included in the preprint, indicate the DOI or URL of the preprint. *

https://github.com/teolijo/longevitY/blob/main/pipelineYou should fill this box only if you chose 'Codes have been used in this study'. URL must start with http:// or https://

Keywords (optional)

transposable elements, lifespan, sex chromosomes, toxic Y effect, transcriptomics, differential expression analysis

Methods that require specific expertise (optional)

NonePlease indicate the methods that may require specialised expertise during the peer review process (use a comma to separate various required expertises).

Thematic fields *

Evolutionary genomics

Suggested reviewers - Suggest up to 10 reviewers (provide names and Email addresses). (Optional)

Cedric Freschotte cf458@cornell.edu, Sarah Schaack schaackmobile@reed.edu, Miguel Branco ku.ca.lumq@ocnarb.m, Paul Jay paul.yann.jay@gmail.com, Tamas Szekely t.szekely@bath.ac.uk, Cedric Feschotte [cf458@cornell.edu] suggested: Kateryna Makova, Penn State , Butterweck Andrea [abebert6+7@gmail.com] suggested: Sorry, but as membre of the managing board, it is difficult for me to act as a reviewer., Butterweck Andrea [abebert6+7@gmail.com] suggested: all the best and thanks for having taking into hands this preprint!, Butterweck Andrea [abebert6+7@gmail.com] suggested: Denis, Sarah Schaack [schaackmobile@reed.edu] suggested: So sorry to delay! I was hoping I could do this, but we are just starting the semester, and it is just too much of a crush of work., Sarah Schaack [schaackmobile@reed.edu] suggested: Potential reviewer:, Sarah Schaack [schaackmobile@reed.edu] suggested: Igor Rogozin (rogozin@ncbi.nlm.nih.gov) or folks in his group, Josefa González suggested: Gael Cristofari, Francois Sabot suggested: Unfortunately, I recently published with Dr Marie Fablet..., Francois Sabot suggested: I may recommand Dr Yann Bourgeois; yann.bourgeois@ird.fr or Dr Christine Tranchant-Dubreuil christine.tranchant@ird.fr, Clémentine Vitte suggested: Sorry Ana-Sophie, I am very busy at the moment and cannot handle the manuscript., Clémentine Vitte suggested: Maybe you can ask:, Clémentine Vitte suggested: Cédric Feschotte: cf458@cornell.edu, Clémentine Vitte suggested: Clément Gilbert: clement.gilbert1@universite-paris-saclay.fr, Clémentine Vitte suggested: Richard Cordaux: richard.cordaux@universite-paris-saclay.fr, Clémentine Vitte suggested: Cheers,, Clémentine Vitte suggested: Clémentine No need for them to be recommenders of PCI Genomics. Please do not suggest reviewers for whom there might be a conflict of interest. Reviewers are not allowed to review preprints written by close colleagues (with whom they have published in the last four years, with whom they have received joint funding in the last four years, or with whom they are currently writing a manuscript, or submitting a grant proposal), or by family members, friends, or anyone for whom bias might affect the nature of the review - see the code of conduct

Opposed reviewers - Suggest up to 5 people not to invite as reviewers. (Optional)

Casey Bergman ude.agu@namgrebc, Julien Blumenstiel jblumens@ku.edue.g. John Doe [john@doe.com]

Submission date

2023-08-18 15:01:38

Recommender

Anna-Sophie Fiston-Lavier

Reviewers

Anonymous, Igor Rogozin , Paul Jay , Anonymous

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