BOTIGUÉ Laura's profile
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BOTIGUÉ Laura

  • Genomics of ancient crops and domestication, Centre for Research in Agricultural Genomics, Barcelona, Spain
  • Bioinformatics, Evolutionary genomics, Population genomics
  • recommender

Recommendation:  1

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Areas of expertise
I finished my PhD in 2012 in the Evolutionary Biology Institute (IBE) in Barcelona under the supervision of David Comas, where I studied the population structure and admixture of human North African populations using mitochondrial and SNP array data. After that I did a three year Postdoc at Stony Brook University (NY) with Brenna Henn, in the Department of Ecology and Evolution, where I worked on the analysis of next generation sequencing data to investigate mutational load and the accumulation of deleterious mutations in human populations, delving into 1970s classic theories of population genetics and statistics. I also worked on the analysis of two Neolithic dog genomes from Germany, following my interest on this emerging field and the potential it harbors in our understanding of the past. Finally, I was invited to join efforts with the H3Africa Consortium to study novel and rare variation in an outstanding genomic dataset of African populations. After working for a year in the Bioinformatic team of the Plant and Fungal Tree of Life Project at Kew Royal Botanic Gardens (London), on January 2018 I joined the Centre for Research in Agricultural Genomics as a group leader to study plant domestication by analysing ancient and modern genomes. You can check our first work in this topic in Scott, Botigué et al. Nature Plants.

Recommendation:  1

23 Aug 2022
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A novel lineage of the Capra genus discovered in the Taurus Mountains of Turkey using ancient genomics

Goat ancient DNA analysis unveils a new lineage that may have hybridized with domestic goats

Recommended by based on reviews by Torsten Günther and 1 anonymous reviewer

The genomic analysis of ancient remains has revolutionized the study of the past over the last decade. On top of the discoveries related to human evolution, plant and animal archaeogenomics has been used to gain new insights into the domestication process and the dispersal of domestic forms.

In this study, Daly and colleagues analyse the genomic data from seven goat specimens from the Epipalaeolithic recovered from the Direkli Cave in the Taurus Mountains in southern Turkey. They also generate new genomic data from Capra lineages across the phylogeny, contributing to the availability of genomic resources for this genus. Analysis of the ancient remains is compared to modern genomic variability and sheds light on the complexity of the Tur wild Capra lineages and their relationship with domestic goats and their wild ancestors.

Authors find that during the Late Pleistocene in the Taurus Mountains wild goats from the Tur lineage, today restricted to the Caucasus region, were not rare and cohabited with Bezoar, the wild goats that are the ancestors of domestic goats. They identify the Direkli Cave specimens as a lineage separate from the 
West and East Caucasus Tur modern lineages. Also, analysis of the genomic data and mitochondrial haplotypes reveals hybridization between the Tur and the Bezoar wild lineages. Interestingly, authors also find an uneven amount of Tur ancestry among Neolithic domestic goats, with European domestic goats showing evidence of this ancient Tur ancestry, whereas Neolithic Iranian domestic goats do not, a pattern that is also observed in some modern European domestic goats.

A modified D statistic, Dex, is developed to examine the contribution of the ancient Tur lineage in domestic goats through time and space. Dex measures the relative degree of allele sharing, derived specifically in a selected genome or group of genomes, and may have some utility in genera with complex admixture histories or admixture from ghost lineages. Results confirm that Neolithic European goat had an excess of allele sharing with this ancient Tur lineage, something that is absent in contemporary goats eastwards or in modern goats.

Interspecific gene flow is not uncommon among mammals, but the case of Capra has the additional motivation of understanding the origins of the domestic species. This work uncovers an ancient Tur lineage that is different from the modern ones and is additionally found in another geographic area. Furthermore, evidence shows that this ancient lineage exhibits substantial amounts of allele sharing with the wild ancestor of the domestic goat, but also with the Neolithic Eurasian domestic goats, highlighting the complexity of the domestication process.

This work has also important implications in understanding the effect of over-hunting and habitat disruption during the Anthropocene on the evolution of the Capra genus. The availability of more ancient specimens and better coverage of the modern genomic variability can help quantifying the lineages that went lost and identify the causes of their extinction.

This work is limited by the current availability of whole genomes from modern Capra specimens, but pieces of evidence as well that an effort is needed to obtain more genomic data from ancient goats from different geographic ranges to determine to what extent these lineages contributed to goat domestication.

References

Daly KG, Arbuckle BS, Rossi C, Mattiangeli V, Lawlor PA, Mashkour M, Sauer E, Lesur J, Atici L, Cevdet CM and Bradley DG (2022) A novel lineage of the Capra genus discovered in the Taurus Mountains of Turkey using ancient genomics. bioRxiv, 2022.04.08.487619, ver. 5 peer-reviewed and recommended by Peer Community in Genomics. https://doi.org/10.1101/2022.04.08.487619

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BOTIGUÉ Laura

  • Genomics of ancient crops and domestication, Centre for Research in Agricultural Genomics, Barcelona, Spain
  • Bioinformatics, Evolutionary genomics, Population genomics
  • recommender

Recommendation:  1

Reviews:  0

Areas of expertise
I finished my PhD in 2012 in the Evolutionary Biology Institute (IBE) in Barcelona under the supervision of David Comas, where I studied the population structure and admixture of human North African populations using mitochondrial and SNP array data. After that I did a three year Postdoc at Stony Brook University (NY) with Brenna Henn, in the Department of Ecology and Evolution, where I worked on the analysis of next generation sequencing data to investigate mutational load and the accumulation of deleterious mutations in human populations, delving into 1970s classic theories of population genetics and statistics. I also worked on the analysis of two Neolithic dog genomes from Germany, following my interest on this emerging field and the potential it harbors in our understanding of the past. Finally, I was invited to join efforts with the H3Africa Consortium to study novel and rare variation in an outstanding genomic dataset of African populations. After working for a year in the Bioinformatic team of the Plant and Fungal Tree of Life Project at Kew Royal Botanic Gardens (London), on January 2018 I joined the Centre for Research in Agricultural Genomics as a group leader to study plant domestication by analysing ancient and modern genomes. You can check our first work in this topic in Scott, Botigué et al. Nature Plants.